This study evaluated the in vitro potential of cocoa pod husk (CPH) pectin as a carrier for chronodelivery of hydrocortisone\nintended for adrenal insufficiency. FTIR studies found no drug-CPH pectin interactions, and chemometric analysis showed that\npure hydrocortisone bears closer similarity to hydrocortisone in hot water soluble pectin(HWSP) than hydrocortisone in citric acid\nsoluble pectin (CASP). CPH pectin-based hydrocortisone matrix tablets (âË?¼300mg) were prepared by direct compression and wet\ngranulation techniques, and the tablet cores were film-coated with a 15% HPMC formulation for timed release, followed by a 12.5%\nEudragit S100 formulation for acid resistance. In vitro drug release studies of the uncoated and coated matrix tablets in simulated\ngastrointestinal conditions showed that wet granulation tablets exhibit greater retardation of drug release in aqueous medium than\ndirectly compressed tablets. CASP showed greater suppression of drug release in aqueous medium than HWSP. Wet granulation\nHWSP-based matrix tablets coated to a final coat weight gain of âË?¼25%w/w were optimized for chronodelivery of hydrocortisone\nin the colon.The optimized tablets exhibited a lag phase of âË?¼6 h followed by accelerated drug release in the colonic region and have\npotential to control night time cortisol levels in patients with adrenal insufficiency.
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